Clinic of Pulmonary Medicine and Respiratory Cell Research

Description

The Clinic of Pulmonary Medicine at University Hospital Basel is specialised on chronic inflammatory lung diseases such as asthma, COPD and lung fibrosis.

Our mission is to improve the understanding of the pathogeneses of the above named diseases and find new targets for diagnosis and therapies. To achieve these goals, we link clinical studies with studies of cell molecular biology in isolated primary human lung cells. This translational research approach resulted in the characterisation of novel biomarkers for COPD and asthma as well as for new cell specific pathologies, which are essential for the progression of the diseases.

Supported by the ERS, The Swiss National Foundation, The Swiss Government Excellent Scholarship for foreign researchers and OPEC Fund for International Development (OFID), we were able to train and teach several MDs and pulmonary scientists to improve their skills, help them in their career development and bring back new knowledge to their home countries.

International Experience

Since 2010, supported by funds from ERS fellowships, The Swiss National Foundation, The Swiss Government Excellent Scholarship for foreign researchers and OPEC Fund for International Development (OFID), we have hosted 10 MDs and PhDs from Greece (2), China (4), Bangladesh (2) and Nepal (2) respectively. According to the needs of their respective training program and career requirement, each of them received a appropriate training in patient diagnostics and therapy, as well as in molecular cell biology of tissue forming lung cells. All trainees were involved in our studies and included in resulting publications in peer reviewed medical and scientific journals.

Research infrastructure

Our research unit includes our own cell culture facilities (biosafety level II) to isolate and expand human primary tissue forming lung cells from biopsies obtained by our clinic from patients with asthma, COPD or fibrosis. The available equipment includes all facilities for analysis of proteins, RNA, microRNA and DNA. We have access to confocal microscopes, lapse-time microscopy, real-time and quantitative PCR.

Our research is funded by ERS, The Swiss National Foundation, The Swiss Government Excellent Scholarship for foreign researchers and OPEC Fund for International Development (OFID). For screening of new drugs, we received funding from leading pharmaceutical companies, and we collaborate with new promising start-up enterprises.

Prof. M. Tamm has built up a new concept for inter-disciplinary patient monitoring and care system, which is unique for Switzerland. Prof. D. Stolz is the reference specialist on COPD and the only specialist for thermoplasty therapy of severer asthma in Switzerland. Prof. M. Roth is the PhD with focus on cell biology of tissue forming lung cells and its regulation by disease specific factors. Recently, we provided evidence of a new epigenetic regulatory mechanism (PRMT1 signalling), which can explain many cellular pathologies causing tissue remodelling in asthma and COPD.

  • Host center eligibility:

    European fellowships\ Global fellowships (return phase only)

  • Research areas:

    Asthma\ Biomarkers\ COPD\ Epigenetics\ Epithelial cell\ Molecular biology

  • Type of research:

    Basic Science\ Clinical Science\ Translational Research

  • Address:

    University Hospital Basel,
    Petersgraben 4,
    CH-4031, Basel, Switzerland

  • Contact person 1:

    Michael Roth

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